The Nittany Lions moved up two spots in this week's AP Top 25 poll.
Freiermuth made eight catches for 99 yards and added a pair of touchdowns in Penn State's big victory over Buffalo.
Dotson led the Nittany Lions with four receptions worth 109 yards on the night.
Reid's 36-yard pick-six of Matt Myers gave Penn State a lead it wouldn't relinquish for the remainder of Saturday's 45-13 win over Buffalo.
The Nittany Lions woke up in the second half and took care of business against the Bulls.
The 25-16, 25-11, 25-16 win is Penn State's fifth-straight sweep of the season.