The Nittany Lions and Hawkeyes' week 7 contest will be broadcast nationally on ABC.
Kaitlyn Hord's team-high 11 kills gave the Nittany Lions a much-needed boost in the 25-19, 25-17, 25-21 victory against the Hawkeyes.
Wade made a Penn State-leading 11 tackles and seemed to be everywhere on Saturday afternoon at Beaver Stadium.
Cain led the Nittany Lions with 105 rushing yards and provided a much-needed spark to an otherwise pedestrian second-half offense.
Penn State sacked Purdue quarterback Jack Plummer 10 times and held the Boilermakers to -19 rushing yards on Saturday.
Despite an ugly offensive performance in the second half, Penn State's defense made sure that the Boilermakers had no chance of coming back in this one.