The Nittany Lions fell behind early and never recovered.
Kerkvliet is set to return for his sixth and final year of NCAA eligibility.
The Nittany Lions had three hits in nine innings.
Henderson became the 13th player to join Penn State's Class of 2025.
Meiga has two years of eligibility remaining.
Wylie didn't appear in the Blue-White Game last month and was absent during the last few media availability of spring practice.