In the penultimate game of the regular season, the Nittany Lions are again multiple-score favorites over their opponents.

This week, Penn State travels to Minnesota to face the Golden Gophers at 3:30 p.m. on Saturday, November 23, in Minneapolis’s Huntington Bank Stadium. DraftKings set the opening line for the game at -12 points in favor of the Nittany Lions, paired with an over/under set at 45 points. The money line for the game reads -440 in favor of the blue and white, making Minnesota a +340 underdog.

In the last 10 matchups between the two Big Ten opponents, the Nittany Lions lead 6-4 in the head-to-head battle with a 5-4-1 record against the spread, according to OddsShark. The last time Minnesota defeated Penn State was a 31-26 upset in 2019.

After its victory last week against Purdue, Penn State is 5-5 against the spread and 3-7 playing toward the over/under.

Pick Of The Week

Penn State -3.5 first-quarter spread at +110.

The Nittany Lions have outscored their last three opponents 31-7 in the first quarter. On the other hand, Minnesota has been held to three points or less in the first quarter of seven of their 10 games, making the small margin of 3.5 points eye-catching for the quick-starting Penn State offense.