The decision reverses a lower court's 2019 ruling that found Spanier's conviction to be unconstitutional.
The center is currently treating 13 coronavirus-positive inpatients aged 33 to 96.
Residents of the house, which is converted into three apartments, evacuated.
A new mini-casino could be coming to Centre County in the near future.
"They’re going to suffer. There’s no doubt about it."
The borough will implement changes in August to control traffic and limit coronavirus spread.