Omar Cooper Jr.'s go-ahead toe-tap touchdown in the final minute sealed Penn State's sixth consecutive loss.
The Nittany Lions will play their first home game without James Franklin since 2013.
James Franklin was fired almost a month ago, but Penn State still hasn't played at home since the program-altering move.
Penn State's new international quarter of Melih Tunca, Ivan Jurić, Tibor Mirtič, and Saša Ciani combined for 41 points in the Nittany Lions' season-opening win.
The Maryland native took an official visit with his hometown school just four days after his decommitment from Penn State.
Penn State needs to play Koby Howard more.