Brezina totaled 51 tackles, three tackles for loss, one forced fumble, and one fumble recovery across his Cyclone career.
Penn State has now lost at The Palestra two years in a row.
The Lady Lions recorded 18 offensive rebounds in the game.
Penn State is the only team to score 70+ points against Michigan State this season.
A coaching search that provided no coach for nearly two months somehow produced $370 million for everyone else.
The Lady Lions gave up 36 fourth-quarter points.