Makenna Marisa posted 21 points, but the Lady Lions couldn't keep up with the Hoosiers Monday night.
Penn State has opened as a three-point favorite for its Outback Bowl matchup against Arkansas.
First Night State College is coming back this year to ring in 2022 after being canceled last year due to the pandemic.
Penn State's 106,799 fans per game ranked behind only Michigan's 108,763 during the 2021 football season.
Blum is one of 15 professors participating in the tournament and competing for a $100,000 grand prize.
The Outback Bowl matchup will mark Penn State's first game against Arkansas in program history.