Siyeh Frazier and Kamaria McDaniel each scored a team-high 22 points in the loss, but their efforts weren't enough to earn Penn State's second conference win.
A four-goal first period powered the Nittany Lions to a big win on the road.
Penn State had its lowest-scoring performance of the season against Wisconsin on Saturday.
"Our sophomore guards, we're asking them to do a heck of a lot, especially when Lamar [Stevens] and Mike [Watkins] are in foul trouble."
Kamaria McDaniel led the Lady Lions in points (24), rebounds (11), and assists (9) en route to powering the team to its first win in Big Ten play.
The former Penn Stater is the first first-round draft pick out of Happy Valley in the last eight years.