Gabby Elliott's 26 points weren't enough for Penn State to overcome two separate 15-point deficits against the Ducks.
The Nittany Lions suffered their second consecutive loss in a blowout to No.13 Illinois.
Scott signed through the 2025 season.
Wilson served as a team captain during the program's 107-match win streak and won four national titles between 2007 to 2010.
This comes after the Nittany Lions went 1-1 during the week, splitting results against Northwestern and Indiana.
The Nittany Lions secured their first win in Big Ten play.