Caitlin Clark and Hannah Stuelke combined for 74 points for the Hawkeyes.
Ace Baldwin Jr. had 18 points in the second half to lead the Nittany Lions past the Hawkeyes.
The Nittany Lions have an overall .500 record with just nine regular season games ahead of the Big Ten Tournament.
Baldwin leads the Big Ten in steals with 2.82 per game.
Zach Hicks and Jameel Brown both scored career-high in points against Big Ten teams in the Nittany Lions' win over Indiana.
The Nittany Lions have eight games remaining in the regular season.