The Nittany Lions will play Michigan in the first round of the Big Ten Tournament.
Head coach Mike Gambino won his 300th career game during the series.
The Nittany Lions were automatic qualifiers after clinching the CHA Championship.
A strong second period wasn't enough for Penn State to extend its Big Ten Tournament hopes after a late goal from Minnesota.
Gretchen Gilmore netted the game-winner early in overtime after crawling back from a 4-0 deficit.
Matt Traynor scored seven times on Penn State's way to victory.