Kayden Mingo's 24 points were not enough in the loss.
The Nittany Lions conclude their regular season with their 29th win.
Penn State controlled the game early on, scoring seven goals in the first quarter.
Allison Oneacre dominated with three home runs in two games.
Despite almost allowing a reverse sweep, the Nittany Lions rallied to earn their first EIVA victory of the season.
Jackson Smith had two goals against the Wolverines.