Penn State was able to ride a two-goal advantage into the second half to put away its conference rivals.
Grant Haus, TJ Malone, and Jack Posey will lead the Nittany Lions this season.
Penn State will host nine home matchups at the Bryce Jordan Center and travel to nine games.
Wiesner was also named the Big Ten's Co-Defender of the Week after her performance against Maryland.
Coming off another conference win, the Nittany Lions emphasized the importance of having each other's backs in the midst of the Big Ten slate.
The Nittany Lions racked up 52 kills en route to their first Big Ten win of the season.