The Nittany Lions held their opponent to 15 shots in their ninth win of the season.
In an action-packed first game of the NCAA tournament, goals from Payton Linnehan, Penelope Hocking, Cori Dyke, and Kate Wiesner propelled the Nittany Lions to the second round.
Penn State will play in its first semifinal game since 2007.
Kashauna Williams notched an impressive 22 kills across Penn State's four-set win over Purdue.
The Nittany Lions committed six penalties in the loss.
A dominant first quarter propelled the Lady Lions to their second win to begin the season.