The Nittany Lions most recently played the Minutemen in a 63-0 win last season.
Barkley ran the ball 24 times for 109 yards during the win.
Rappleyea was ruled out of Saturday's game against Bowling Green.
Penn State's third-down percentage on offense and defense ranks 93rd and 89th, respectively.
The Aussie pinned Bowling Green inside the 20-yard-line twice on Saturday.
Vanover was accused of driving under the influence of marijuana in August.