The Nittany Lions ranking comes following their 51-15 stomping of Maryland and ahead of Michigan.
Lee was one of Linebacker U's most notable members, while Caldwell served with Penn State for several decades.
Nick Scott forced a crucial turnover for the Bengals defense in their win over the Bills on Sunday night.
Is Dante Cephas more than a Band-Aid-solution to Penn State's wide receiver corps issues?
The game also has an over-under set at 44.5 points.
"We need KeAndre to take the next step, Dante, the tight ends to take the next step, because we're going to have to make some plays in the passing game."