A 17-point third quarter powered Penn State to a 41-13 win over Northwestern.
Hamler joins the Colts after three years with the Denver Broncos.
Wide receiver Malick Meiga and Trey Wallace could both miss Saturday's matchup.
The Nittany Lions will kick off against the Wildcats at noon on the Big Ten Network.
The Wildcats are 2-2 this season, including a 37-34 overtime win over Minnesota last week.
While the Nittany Lions are winning games, they're still lacking big plays for big yards.