This will be the second time this season the Nittany Lions play on ABC.
Rhule compiled an 11-27 record with the Panthers since taking over as their head coach in January 2020.
Some former Penn Staters set career-highs during week six of the college football season.
The Nittany Lions are 3-2 against the spread this season.
No top-ten team lost in college football this week.
The former Penn State offensive lineman will play in the XFL if not picked up by an NFL team.