Backup quarterback Jaxon Smolik will miss his second straight game.
The Nittany Lions will play their first home game without James Franklin since 2013.
Penn State has yet to beat a Big Ten opponent this season.
Folks, unfortunately Indiana is just Ohio State in a different shade of red.
James Franklin was fired almost a month ago, but Penn State still hasn't played at home since the program-altering move.
This is the largest spread for the Nittany Lions at home since 2016.