The Nittany Lions held Michigan to just 112 passing yards.
Lee had a breakout performance with 134 yards and a touchdown on the ground.
"He had a great performance today, and I know he's gonna continue to play great football. That's what I expect from Sean Clifford."
Penn State fans quickly took to Twitter to berate Harbaugh and celebrate for the first time in what feels like forever.
Penn State picked up its first win of the season Saturday afternoon in Ann Arbor.
Jamari Wheeler led the team with 18 points and five steals, while Myreon Jones, Seth Lundy, and Sam Sessoms added 12 points each.