Penn State had the lead heading into the final inning, but the defense collapsed as the Badgers drove in four more runs.
Mesenbrink won every match but one by bonus points this season.
Penn State put a record-tying six wrestlers in the NCAA finals.
This is Penn State's fifth straight NCAA team title.
The national champs also broke their own record for most team points.
The Nittany Lions bounced back to tie the series.