The Nittany Lions will not make the Big Ten Tournament after the loss to No. 15 Maryland.
Loosli shut down the Tribe with a one-run lead in the bottom of the ninth.
Penn State ended the season with its 10th consecutive loss.
The Nittany Lions earned three wins against Robert Morris, Radford, and Villanova during the Hokie Invite.
A late five-minute major against Penn State set Minnesota up with a perfect chance to take the lead, which it did.
That's six wins in a row for the Nittany Lions.