The Nittany Lions are set to be joined by Clemson, San Francisco, and Fordham.
Olu Fashanu to New Orleans is a popular pick in recent mock drafts.
Isaac led the Nittany Lions with 7.5 sacks last season.
Kyle Lehman and TJ Malone each earned weekly awards from the Big Ten on Tuesday.
A large group joined alum Paul Johnson on his trek though State College during his run from Los Angeles to New York City.
"Throughout the rollercoaster that was our time together, one thing persisted: you always welcomed me with open arms."