The Nittany Lions were 20-point underdogs during the two teams' last White Out meeting at Beaver Stadium.
Taylor Leath and Allyson Cathey combined for 31 kills Sunday afternoon in Columbus, but the Buckeyes prevailed 3-1.
There was no 300 moment for the Spartans in Happy Valley as three Penn Staters doubled up on the day.
The Nittany Lions will host Ohio State for the annual White Out game at 7:30 p.m. Saturday.