Penn State went 3-1 down in the second period, but five unanswered goals gave the Nittany Lions their first road sweep of the 2019-20 season.
College GameDay will prelude the Penn State-Ohio State matchup for the third consecutive season.
Sucese broke Andrew Sturtz's program record of 54 goals against Minnesota on Saturday night.
From Journey Brown's 100-yard day to Sean Clifford's two scores on the ground, Penn State's run game was firing on all cylinders against Indiana.
"Our offensive line was asking for the ball. As a quarterback, when your offensive line is asking to go for it on 4th and one, you know what you need to do."
Hamler went down with an injury after taking an awkward fall at the end of a kickoff return late in the first quarter and didn't return.