The No. 3 Nittany Lions and No. 4 Blue Jays spilt the season series in 2021.
The Nittany Lions lost game four in heartbreaking walk-off fashion.
Pickett is a previous recipient of the Metro Atlantic Athletic Conference Player of The Year award.
Both goalies stood on their heads, but Dylan Foulds' clutch performance in the final seconds was enough for a key victory.
The Nittany Lions will host the entire tournament's slate of games at Panzer Stadium.
Frazier is currently completing a 10-day contract with the Grizzlies.