The blue and white showed flashes of momentum but ultimately could never match the Wolverines' answers during the first game of the weekend series.
The Nittany Lions extended their three-game win streak as the season begins to wind down.
Qudas Wahab recorded his second double-double of the season, totaling 14 points and 12 rebounds.
Penn State will move on to the Sweet Sixteen after shutting out the Broncos.
"If you get into a heated family debate over the game or Penn State football in general, take a shot. You're gonna need it."
The Scarlet Knights come to Beaver Stadium boasting a winning record and bowl eligibility.