According to its online portal, the arena will begin administering vaccines on Friday, April 9.
About 3% of COVID-19 tests administered this week returned positive results.
The hospital is currently treating 25 virus-positive inpatients aged between 28 and 90 years old.
Although COVID-19 vaccine eligibility will rapidly expand in Pennsylvania next month, Penn State isn't ready to require shots for students and employees just yet.
By April 19, all Centre County adults will be eligible to schedule COVID-19 vaccine appointments.
The hospital has 29 COVID-19 inpatients between the ages of 47 and 90 as of Tuesday morning, an increase of five since Monday.