The defensive tackle heard his name called by the Colts in the sixth round.
Brown is the first Penn State linebacker to be selected in the NFL Draft since Michael Mauti and Gerald Hodges in 2013.
John Reid was picked by the Texans on Saturday afternoon.
Former Penn State football head coach Bill O'Brien was representing State College's Suhey Peppers during the NFL Draft Friday night.
Hamler's NFL dream came true Friday night when he was drafted by the Denver Broncos.
Gross-Matos now becomes the highest drafted Nittany Lion defensive lineman since Jared Odrick in 2010.