Penn State said its support for students, faculty, and staff remains in place.
Collins frequently runs pop-up shops around State College.
Some academic buildings will be left to Misericordia University.
Penn State will be the fourth institution to serve as the host campus since 1999.
Changes were made after over 10 months of focus groups and surveys.
The union workers went on strike in late July, costing the medical center $6.4 million.