After a tight first quarter, the Nittany Lions pulled away with an incredible 11-goal run.
The Nittany Lions are currently in second place in the team standings after the conclusion of the women's competition. The men's competition begins Saturday with finals on Sunday.
Penn State women's soccer has 11 alumnae on rosters in the nine-team league -- the third most of any college program.
O'Donnell's clutch goal 27 seconds into overtime gave Missy Doherty her 100th win as head coach of the Nittany Lions.
Denver is an extremely balanced team with an elite goaltender, solid defense, and plenty of star power up front.
Penn State is currently ranked No. 4 in women's fencing and No. 5 in men's fencing. It joins Notre Dame, Ohio State, and Columbia as the programs ranked inside the top five of the men's and women's divisions.