The Nittany Lions held their own against Michigan until a second half breakdown, falling in their first Big Ten game of the season.
A Sophia Gladiuex hat trick was the difference against the Golden Flashes.
Penn State put the game away early with a three-goal first half.
The Nittany Lions play three matches over the course of Friday and Saturday.
The drop comes after defeating Princeton and drawing Georgetown.
After Monday's loss, the Nittany Lions are refocusing their efforts before battling Michigan on Friday.