Penn State and Minnesota split a two-game series earlier this season.
The Nittany Lions racked up just one win during a five-game stint in North Carolina.
The Nittany Lions were outscored 33-6 this weekend in a completely lopsided series that didn't help Penn State's early-season struggles.
Seth Lundy led Penn State with 20 points, but his efforts weren't enough to take down the Scarlet Knights on their Senior Day.
A late goal from Ryan Kirwan helped Penn State force a game three against the Buckeyes.
Despite three goals and one assist from Mark Sickler and 11 saves by goalie Aleric Fyock, the Nittany Lions couldn't recover after a Quaker goal in the final seconds of the tight matchup.