Isaac's stat line this season is impressive, totaling 12 tackles and five sacks through the Nittany Lions' first five games this season.
The over-under is set at 46.5 points for Saturday's noon kickoff in Columbus.
Our football writers broke down the hottest Penn State takes with perhaps its biggest game of the season ahead.
Rookie Brenton Strange hauled in his first NFL career touchdown in the Jaguars' 37-20 victory over the Colts.
Harvey is the third edge rusher to commit to the recruiting Class of 2024.
Hardy became the first Nittany Lion to have two punt return touchdowns in one game.