The Nittany Lions' defense recorded its second shutout of the season.
Both the Nittany Lions and the Buckeyes are undefeated going into the matchup.
The Nittany Lions were aided by three touchdown passes from Drew Allar, as well as two punt return touchdowns from Daequan Hardy.
Tight end Khalil Dinkins and offensive lineman JB Nelson were listed as out.
Saturday's Homecoming game should be a rainy, windy affair.
UMass is 1-6 this season, with its lone win being a 41-30 victory over New Mexico State.