Reid's 36-yard pick-six of Matt Myers gave Penn State a lead it wouldn't relinquish for the remainder of Saturday's 45-13 win over Buffalo.
The Nittany Lions woke up in the second half and took care of business against the Bulls.
The 25-16, 25-11, 25-16 win is Penn State's fifth-straight sweep of the season.
Here's everything you'll need to know for Penn State's first night game of the season.
Friday's regular season match was played at a pace fitting for a playoff final. A goal from Ally Schlegel and some breathless defending maintained Penn State's four-game unbeaten streak.
Kaitlyn Hord recorded a match-high 12 kills en route to leading the Nittany Lions past the Cyclones 25-22, 25-16, 25-15.