The Nittany Lions scored seven goals in the second half, giving Hannah Prince her first win as Penn State's head coach.
Four golds and one bronze were secured among the six wrestlers with Penn State ties.
A late rally from High Point forced set five, which Penn State captured despite another Wildcat comeback.
The Nittany Lions' next game is now scheduled for September 4.
The Penn State freshmen made their mark on the Nittany Lions' first win of the season.
Sandusky has claimed his innocence since the 2012 trial.
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