Evan Bell scored a pair of goals, and Brandon Biro, Evan Barratt, and Max Sauvé also found the back of the net on Sunday afternoon at Pegula Ice Arena.
The Nittany Lions moved up two spots after beating Purdue 35-7 on Saturday afternoon.
Penn State Athletics hasn't confirmed a kickoff time or network assignment yet, but Fowler said "we'll be there" for the White Out game while tweeting back and forth with a Penn State fan.
The Nittany Lions and Hawkeyes' week 7 contest will be broadcast nationally on ABC.
Wade made a Penn State-leading 11 tackles and seemed to be everywhere on Saturday afternoon at Beaver Stadium.
Cain led the Nittany Lions with 105 rushing yards and provided a much-needed spark to an otherwise pedestrian second-half offense.