Simmons missed Penn State's first five games of the season because of an undisclosed injury suffered in training camp.
Kerry Collins, Bobby Engram, and Brian O'Neal led a furious comeback to secure Penn State's first Big Ten era victory over the Spartans.
Saquon Barkley eclipsed 100 totals yards for the fifth consecutive game, and DaeSean Hamilton had his first big game for Denver.
Athletics advises fans only to purchase tickets to Penn State home games from the university's Ticket Office and Ticketmaster.
The mid-afternoon clash will air on either ABC or ESPN.
Barkley recorded 129 yards from scrimmage and two touchdowns in the Giants' 33-31 loss to the Panthers Sunday.