The Nittany Lions enter next weekend's contest against the Buckeyes as two-possession underdogs.
The Nittany Lions took down Indiana 34-27 on Saturday, and they stayed put in the AP Top 25 poll as a result.
College GameDay will prelude the Penn State-Ohio State matchup for the third consecutive season.
From Journey Brown's 100-yard day to Sean Clifford's two scores on the ground, Penn State's run game was firing on all cylinders against Indiana.
"Our offensive line was asking for the ball. As a quarterback, when your offensive line is asking to go for it on 4th and one, you know what you need to do."
Hamler went down with an injury after taking an awkward fall at the end of a kickoff return late in the first quarter and didn't return.