Omar Cooper Jr.'s go-ahead toe-tap touchdown in the final minute sealed Penn State's sixth consecutive loss.
Backup quarterback Jaxon Smolik will miss his second straight game.
The Nittany Lions will play their first home game without James Franklin since 2013.
Penn State has yet to beat a Big Ten opponent this season.
Folks, unfortunately Indiana is just Ohio State in a different shade of red.
James Franklin was fired almost a month ago, but Penn State still hasn't played at home since the program-altering move.