Goals from Payton Linnehan and Rachel Wasserman as well as a standout performance from goalkeeper Amanda Dennis sealed a convincing quarterfinal win for the Nittany Lions.
Nebraska snapped Penn State's eight-match winning streak with the dramatic five-set victory.
The final tournament selection, in which the committee will name the 48 teams chosen to compete in the College Cup, will take place on November 18th.
Kamaria McDaniel's double-double led Penn State women's basketball to a preseason win over Kutztown Friday night.
The Nittany Lions now lead the Hawkeyes 55-0 in the all-time series, which dates back to 1991.
Sam Sternschein's goal with 8:10 to play in the third period stood up as the game-winner on Friday night.