Wade made a Penn State-leading 11 tackles and seemed to be everywhere on Saturday afternoon at Beaver Stadium.
Cain led the Nittany Lions with 105 rushing yards and provided a much-needed spark to an otherwise pedestrian second-half offense.
Penn State sacked Purdue quarterback Jack Plummer 10 times and held the Boilermakers to -19 rushing yards on Saturday.
Despite an ugly offensive performance in the second half, Penn State's defense made sure that the Boilermakers had no chance of coming back in this one.
Need information on Saturday's Homecoming Game? We've got you covered.
It's just James Franklin being James Franklin.