Wade made a Penn State-leading 11 tackles and seemed to be everywhere on Saturday afternoon at Beaver Stadium.
Cain led the Nittany Lions with 105 rushing yards and provided a much-needed spark to an otherwise pedestrian second-half offense.
Penn State sacked Purdue quarterback Jack Plummer 10 times and held the Boilermakers to -19 rushing yards on Saturday.
Shaw and Purnell are both seniors majoring in biology, and Shaw is double-majoring in psychology as well.
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Penn Staters gathered to guard the Lion Shrine and participate in one of the university's time-honored Homecoming traditions.