Finegan broke his tibia and fibula in the third quarter of Buffalo's 45-13 defeat to Penn State on Saturday night.
Penn State will play Pitt for the 100th time in program history this Saturday.
The Nittany Lions are favored to beat Pitt for the third consecutive season.
The Nittany Lions moved up two spots in this week's AP Top 25 poll.
Freiermuth made eight catches for 99 yards and added a pair of touchdowns in Penn State's big victory over Buffalo.
